Study on pharmacokinetics of crebanine injection in rabbits.
- Author:
Yun-Shu MA
1
;
Qing-Jie SHANG
;
Yi-Cen BAI
;
Xiao-Fei MENG
;
Shao-Jian KANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aporphines; administration & dosage; blood; pharmacokinetics; Chromatography, High Pressure Liquid; Female; Injections; Male; Metabolic Clearance Rate; Plants, Medicinal; chemistry; Rabbits; Stephania; chemistry
- From: China Journal of Chinese Materia Medica 2007;32(7):630-632
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo develop an HPLC method for the determination of serum level of Crebanine (Cre) and study on the pharmacokinetics of Cre injection in rabbits.
METHODTo sample blood serum from the rabbits' ears which were injected the Cre by 2.0 mg x kg(-1) at different time and use HPLC to determine the concentration of Cre in it, the pharmacokinetic parameters were accessed by the DAS software.
RESULTCre was fitted to a two compartment open pharmacokinetic model in rabbits. There was no signifiant difference between the male and female rabbits'pharmacokinetic by t-test. The mainly pharmacokinetic parameters were: t1/2alpha = (3. 246 +/-0.222) min, t1/2beta = (36.67+/-5.52) min, Cmax = (1.401 +/- 0.062) mg x L(-1), Vd = (5.928 +/- 0.877) L x kg(-1), Cl = (0. 051 +/-0.003) L x min(-1) x kg(-1).
CONCLUSIONThis experiment can objectively show the pharmacokinetics regularity of Crebanine injection in rabbits. Crebanine injection was a speeding disposition drug (t1/2 <1 h) and disposed extensively and rapidly in rabbits.
