Preparation of liposome entrapped vincristine sulfate and mitoxantrone chlorhydric acid.
- Author:
Tong CHEN
1
;
Shi-xiang HOU
;
Yong-yan WANG
;
Wen-sheng ZHANG
;
Bi-qiong SHI
Author Information
- Publication Type:Journal Article
- MeSH: Delayed-Action Preparations; chemistry; Drug Compounding; methods; Hydrogen-Ion Concentration; Liposomes; chemistry; Mitoxantrone; chemistry; Particle Size; Technology, Pharmaceutical; methods; Vincristine; chemistry
- From: China Journal of Chinese Materia Medica 2007;32(8):678-681
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the prepation of the liposome carried with vincristine sulfate (VCR) and mitoxantrone chlorhydric acid (MTO) and to evaluate the quality of the liposome.
METHODThe liposome carried with VCR and MIT was prepared by pH-gradients method and reverse evaporation technique. HPLC was employed to determine VCR and MIT entrapping efficiency of liposomal. Laser particle analyzer was applied to determine the size and zeta potential of the liposomes carried with VCR and MTO.
RESULTThe mean diameter of the liposome carried with MIT and VCR was 72.22 nm, with the entrapping rate of 95.77% for VCR and 99.53% for MTO. The liposome had perfect shape.
CONCLUSIONThe liposomes with high entrapping rate and small particle size had been prepared by pH-gradient method and reverse evaporation technique.
