Comparative study on in vitro drug-release between Tuizhang ophthalmic gel and Tuizhang oculentum.
- Author:
Guo-hua WANG
1
;
Qi-xia NIE
;
Hui LI
;
Chen ZANG
;
Bao-xian ZHANG
;
Xiao-mei ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Acrylic Resins; chemistry; Anthraquinones; chemistry; pharmacokinetics; Delayed-Action Preparations; chemistry; pharmacokinetics; Drugs, Chinese Herbal; chemistry; pharmacology; Emodin; chemistry; pharmacokinetics; Gels; Ointments; Plants, Medicinal; chemistry; Solubility; Technology, Pharmaceutical; methods
- From: China Journal of Chinese Materia Medica 2007;32(8):683-687
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare tuizhang gel to cure cataract, the characteristics of Tuizhang gel on the drug-releasing in vitro were evaluated by compared with Tuizhang oculentum.
METHODThe emodin and chrysophanol in the releasing mediator were determined by HPLC, and the drug releasing characteristics of Tuizhang gel and Tuizhang oculentum were studied by bag filter method.
RESULTThe emodin and chrysophanol in Tuizhang gel released (98.3, 1.1)%, (95.8, 1.8)% within 24 hours, respectively, while those in tuizhang oculentum released (10.62, 0.7)%, (10.46, 0.4)%, respectively. The emodin and chrysophanol in Tuizhang gel released more quickly and completely than in Tuizhang oculentum, so Tuizhang gel has enhanced the bioavailability.
CONCLUSIONThe Tuizhang gel is characterized by slow-release to some degree, and it shows a promising future on ophthalmic drug delivery.
