Effect of Suanzaoren decoction on acute hepatic failure in mice.
- Author:
Hai-peng ZHU
1
;
Zhi-liang GAO
;
De-ming TAN
;
Yan-dan ZHONG
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Animals; Aspartate Aminotransferases; blood; Cytokines; metabolism; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Free Radicals; metabolism; Galactosamine; Glutathione; metabolism; Lipopolysaccharides; Liver; drug effects; metabolism; pathology; Liver Failure, Acute; blood; chemically induced; prevention & control; Male; Malondialdehyde; metabolism; Mice; Nitric Oxide; metabolism; Nitric Oxide Synthase; metabolism; Random Allocation; Superoxide Dismutase; metabolism
- From: China Journal of Chinese Materia Medica 2007;32(8):718-721
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of Suanzao nacute hepatic failure in mice.
METHODAcute liver failure was induced in male Kunming strain mice by enterocoelia injecting the animals with D-Gal-N and LPS. The mice in treatment groups were given corresponding drug 2 h before administration of D-Ga1-N and LPS, and the mice in control group were given the same dose of distilled water. The 24 h survival rate, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels were compared. Serum the levels of TNF-alpha and IL-1 and the levels of SOD, MDA, GR, GSH, NO and NOS in the liver were determined.
RESULTTreatment with suanzaoren decoction could increase the survival rate and improve the liver histological feather. Suanzaoren decoction inhibited the serum the levels of ALT, AST, TNF-alpha and IL-1, and reduced the levels of MDA, NO and NOS and increased the levels of GR and SOD in the liver.
CONCLUSIONTreatment with Suanzaoren decoction can suppress the D-Gal-N/LPS-induced acute hepatic failure. It may be the mechanism that Suanzaoren decocotion regulate the production of inflammatory cytokines and free radicals.
