Effects of aqueous extract of Hedysarum austrosibiricum on metabolism of oxyen free radicals in subacute aging mice caused by D-galactose.
- Author:
Taoerdahong HAILIQIAN
1
;
Jin-sen KANG
;
Lian SUN
Author Information
- Publication Type:Journal Article
- MeSH: Aging; drug effects; metabolism; Animals; Antioxidants; isolation & purification; pharmacology; Brain; drug effects; metabolism; Drugs, Chinese Herbal; isolation & purification; pharmacology; Fabaceae; chemistry; Female; Free Radical Scavengers; isolation & purification; pharmacology; Free Radicals; metabolism; Galactose; toxicity; Glutathione Peroxidase; metabolism; Liver; drug effects; metabolism; Malondialdehyde; metabolism; Mice; Monoamine Oxidase; metabolism; Plant Extracts; isolation & purification; pharmacology; Plant Roots; chemistry; Random Allocation; Superoxide Dismutase; metabolism
- From: China Journal of Chinese Materia Medica 2007;32(8):729-731
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the anti-aging effect of aqueous extract of Hedysarum austrosibiricum cultivated in Xin-jiang.
METHODSubacute aging model in mice was established by D-galactose (D-gal) and activities of SOD and GSH-PX, contents of MDA in brain and liver tissues, activities of MAO in brain tissue and immune indexes were determined.
RESULTAqueous extract of H. austrosibiricum Xinjiang markedly increased the activities of SOD and GSH-PX, significantly decreased contents of MDA in brain and liver tissues. MAO activities in brain tissue were also decreased. It also elevated the spleen and thymus indexes.
CONCLUSIONAqueous extract of H. austrosibiricum might have anti-aging effect, which is implemented by eliminating oxyen free radicals, rising activities
