Preparation and quality evaluation of quercetin self-emulsifyied drug delivery systems.
- Author:
Ying HU
1
;
Hai-Liang CHEN
;
Wen-Quan LIANG
Author Information
- Publication Type:Journal Article
- MeSH: Antioxidants; administration & dosage; chemistry; Butanols; chemistry; Chromatography, High Pressure Liquid; Drug Delivery Systems; Drug Stability; Emulsions; Glycerol; analogs & derivatives; chemistry; Oleic Acids; chemistry; Particle Size; Quercetin; administration & dosage; chemistry; Solubility; Solvents; Technology, Pharmaceutical; methods
- From: China Journal of Chinese Materia Medica 2007;32(9):805-807
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare the quercetin self-emulsified formulation and evaluate its quality.
METHODThe quercetin self-emulsified formulation was optimized based on the quercetin solubility in different oils, and the self-microemulsified efficiency of various combinations of emulsifier and co-emulsifier evaluated using the pseudo-ternary phase diagram. The microemulsion of morphology, size and zeta potential were examined. The quercetin of solubility in self-emulsified system was tested and the formulation stability was investigated by accelerated experiment.
RESULTThe blank self-emulsified system was composed of ethyl oleate/Cremophor EUL/butanol with weight ratio of 10: 54: 36. After being dilutied with water, the morphology of microemulsion was homogeneous small spherical drops observed under the electro-microscopy. The particle size and the zeta potential were 16.3 +/- 4.6 nm and 2.1 +/- 0.8 mV, respectively. The solubility of quercetin in self-emulsifing system was (62.42 +/- 0.11) mg x mL(-1), increased 2 229 folds compared with that of in water. The quality of quercetin self-emulsified formulation was stable during the 3 months storage at 40 degrees C.
CONCLUSIONThe solubility of quercetin is significantly increased in self-emulsified system and the formulation is stable and easy to prepare.
