Effects of Fufang Xiaojingtong capsules on uterine activity of animals.
- Author:
Lan-Fang LI
1
;
Jian-Xin ZHANG
;
Na HAO
;
Li-Jun XIE
;
Guo-Feng LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Capsules; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Female; In Vitro Techniques; Muscle Contraction; drug effects; Muscle, Smooth; drug effects; physiology; Oxytocin; antagonists & inhibitors; Plants, Medicinal; chemistry; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Uterus; drug effects; physiology
- From: China Journal of Chinese Materia Medica 2007;32(9):843-846
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe effects of Fufang Xiaojingtong capsules (FXJTC) on activities of the uterine smooth muscle of the rat in vitro and the uterus of the rabbit in vivo.
METHODThe isolated rat uterine smooth muscle strips were mounted in a Magnus bath containing Locke's solution with a final content of 12.48, 6.24 or 3.12 mg x mL(-1) of FXJTC at 37 degrees C; and 2.0, 1.0 and 0.5 g x kg(-1) of FXJTC and 2.0 g x kg(-1) of Tianqi Tongjing capsules were respectively given to the rabbits through the duodenum, respectively. Their effects on frequency, amplitude and activity of contraction of the rat uterus in vitro and the rabbit uterus in vivo were investigated.
RESULTFXJTC could significantly inhibit the frequency, amplitude and activity of contraction of the normal rat uterus in vitro and decrease the oxytocin-induced increase of contraction of the rabbit uterus in vitro; lowered the frequency, amplitude and activity of contraction of the rabbit uterus in vivo and inhibit the oxytocin-induced the strengthening of contraction of the rabbit uterus in vivo.
CONCLUSIONFufang Xiaojingtong capsules maybe used for treatment of dysmenorrhea induced by spasm of uterine smooth muscle.
