Clinical Effects of Venitol(R) on Complications after Hemorrhoidectomy Prospective Randomized and Placebo-controlled Trial.
- Author:
Heung Woo LEE
;
Woo Yong LEE
;
Ho Kyung CHUN
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Venitol;
Hemorrhoidectomy;
Bleeding
- MeSH:
Analgesia;
Diosmin;
Hemorrhage;
Hemorrhoidectomy*;
Hesperidin;
Humans;
Length of Stay;
Prescriptions;
Prospective Studies*;
Tablets
- From:Journal of the Korean Society of Coloproctology
1998;14(4):761-766
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Fifty four patients who received closed hemorrhoidectomy were randomized into two parallel groups and treated with Venitol(R)(a micronized flavonoidic fraction containing diosmin 450 mg and hesperidin 50 mg) (group 1) or placebo (group 2). Venitol(R) was administered at the dosage of three toblets b.i.d. the first four days and two tablets b.i.d following three days. Postoperative analgesia and laxative prescription as well as hospital stay were same in two groups. Though there is no difference of symptoms at D1, improvement of symptoms of complications was greater in group 1 than in group 2 at D18. The clinical severity of postoperative spot-bleeding, pain and anal discharge diminished in both groups but to a greater extent in group 1 (P<0.005). There was no side-effects in using Venitol(R). In summary, Venitol(R) is effective in reducing complications after hemorrhoidectomy.
