Relationship of hypoxia-induced factor with tumor angiogenesis in early liver metastasis in colonic cancer.
- Author:
Hao-hui LIANG
1
;
Cheng-you WANG
;
Min XU
;
Shu-bang CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Colonic Neoplasms; metabolism; pathology; Female; Follow-Up Studies; Humans; Hypoxia-Inducible Factor 1; metabolism; Liver Neoplasms; blood supply; secondary; Male; Microvessels; Middle Aged; Neovascularization, Pathologic; Vascular Endothelial Growth Factor A; metabolism
- From: Chinese Journal of Gastrointestinal Surgery 2006;9(4):349-351
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationships of hypoxia-induced factor (HIF) with tumor angiogenesis and early liver metastasis in colonic cancer.
METHODSThirty three cases of colon cancer undergoing radical surgery were divided into two groups according to liver metastasis or not within half a year after operation. Expressions of HIF and vascular endothelial growth factor (VEGF) were examined using immunohistochemical method and tumor microvessel density (MVD) was measured in colonic cancer specimens.
RESULTSFifteen cases developed early liver metastasis, while 18 did not. The positive rates of HIF and VEGF, and MVD were 86.7%, 66.7%, (57.9+/- 12.7)% respectively in the group with early liver metastasis, significantly higher than 44.4% (P< 0.05), 27.8% (P< 0.05) and (22.3+/- 10.2)% (P< 0.01) respectively in the group without early liver metastasis respectively.
CONCLUSIONHIF can promote tumor angiogenesis in colonic cancer, and is closely related with early liver metastasis.
