Expressions and clinical implications of kruppel-like factor 6 and APC in human colorectal carcinoma.
- Author:
Fu-jing WANG
1
;
Mao-peng YANG
;
Hong-liang YU
;
Wei-liang YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adenomatous Polyposis Coli Protein; genetics; Colorectal Neoplasms; genetics; metabolism; pathology; Female; Gene Expression; Genes, APC; Humans; Intestinal Mucosa; metabolism; pathology; Kruppel-Like Factor 6; Kruppel-Like Transcription Factors; genetics; Male; Middle Aged; Neoplasm Staging; Proto-Oncogene Proteins; genetics; RNA, Messenger; genetics
- From: Chinese Journal of Gastrointestinal Surgery 2006;9(5):429-432
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expressions and clinical implications of kruppel-like factor 6(KLF-6) and APC in human colorectal carcinoma.
METHODSThe expressions of KLF-6 and APC in tumor and normal tissues from 32 patients with colorectal carcinoma were investigated by RT-PCR and immunohistochemical technique.
RESULTSThe expression rates of KLF-6 and APC mRNA were 37.5% and 34.3% in tumor tissue, 96.9% and 93.8% respectively in normal tissues (both P< 0.05). The expression rates of KLF-6 and APC protein were 28.1% and 25.0% in colorectal carcinomas, 81.3% and 84.43% respectively in normal tissues (both P< 0.05). There was a significant correlation between the expressions of KLF-6 and APC in colorectal carcinomas (P < 0.05). The expressions of KLF-6 and APC were significantly correlated with tumor differentiation, depth of infiltration, lymph node metastasis and clinical stage (P< 0.05).
CONCLUSIONDown-regulations of KLF-6 and APC might play an important role in the carcinogenesis, development, metastasis of human colorectal carcinoma.
