A new water-soluble lubricant of tablets-L-leucine combined with PEG6000.
- Author:
Wei LIU
1
;
Kai HUANG
;
Xiaoyong RAO
;
Xiaoyan LIU
;
Shasha SUN
;
Xiaojian LUO
Author Information
- Publication Type:Journal Article
- MeSH: Chemistry, Pharmaceutical; Leucine; chemistry; Lubricants; chemistry; Polyethylene Glycols; chemistry; Solubility; Tablets; Water; X-Ray Diffraction
- From: China Journal of Chinese Materia Medica 2011;36(15):2061-2065
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare an effective and water-soluble lubricant.
METHODCo-sprayed lubricant (L-leucine and polyethylene glycol 6000 co-sprayed according to a certain proportion) and mixed lubricant (the physical mixture of spayed L-leucine and crushed polyethylene glycol 6000) were prepared and polyethylene glycol 6000, L-leucine, magnesium stearate, sodium stearyl fumarate and sodium chloride are crushed and sieved, respectively. Residual force, appearance of solution and disintegration time were considered as response variables of the lubrication effect to evaluate different lubricants. The changes of the co-sprayed lubricant were studied by differential scanning calorimetry, fourier infrared, electronic scanning microscope and X-ray diffraction.
RESULTThe efficacy of co-sprayed lubricant is better than other lubricants. Efficacy is improved by external form change without inner components and crystal changes.
CONCLUSIONCo-sprayed lubricant is a good water soluble tablet lubricant which has good efficacy.
