Study on in vitro release of xingnaojing microemulsion.
- Author:
Shan WANG
1
;
Shouying DU
;
Yang LU
;
Xiaolan CHEN
;
Xiao SONG
;
Dongxue LI
Author Information
- Publication Type:Journal Article
- MeSH: Chromatography, High Pressure Liquid; methods; Drugs, Chinese Herbal; chemistry; Emulsions; Molecular Weight
- From: China Journal of Chinese Materia Medica 2011;36(16):2196-2199
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study in vitro release of Xingnaojing microemulsion and to investigate the release mechanism.
METHODThe concentration of jasminoidin was determined by HPLC and the concentration of Aipian was determined by GC. In vitro release characteristics were conducted by dialysis technique. Model fitting was used to determine the kinetics and mechanism.
RESULTJasminoidin released completely within 2 h, fitting the Weibell model best. The release of borneol fitted first order model.
CONCLUSIONThe release mechanisms of different types of medicines are quite different. The different types of medicines dissolve in the different phases in the microemulsion.
