A neuritogenic compound from Tremella fuciformis.
- Author:
Yang ZHANG
1
;
Liang PEI
;
Lijuan GAO
;
Qianming HUANG
;
Jianhu QI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Basidiomycota; chemistry; Drugs, Chinese Herbal; chemistry; isolation & purification; pharmacology; Molecular Structure; Nerve Growth Factor; chemistry; isolation & purification; pharmacology; Neurites; drug effects; PC12 Cells; Rats
- From: China Journal of Chinese Materia Medica 2011;36(17):2358-2360
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo search for low-molecular-weight neuritogenic compounds from the traditional Chinese medicine (TCM).
METHODAn extract library of TCM was prepared. Targeted isolation guided by biological screening led to the discovery of compound 1, and its structure was elucidated by analysis of spectroscopic methods and comparison of spectroscopic data with these reported from the literature.
RESULTA neuritogenic compound 1, 3-O-beta-D-glucopyranosyl-22E, 24R-5alpha, 8alpha-epidioxyergosta-6, 22-diene, was isolated and identified from the methanol extract of T. fuciformis. This compound showed a significant neuritogenic activity against PC12 cells at 3 micromol x L(-1)).
CONCLUSIONMethonal extract of T. fuciformis and targeted compound 1 both showed significant neuritogenic activity against PC12 cells. These results suggested that the extract and compound 1 might be used to prevent and treat neurodegenerative disease such as Alzheimer's disease.
