Expressions of matrix metalloproteinase 9 in mucosal natural killer/T cell and mature T cell lymphomas and its relation to Epstein-Barr virus infection.
- Author:
Zhi-ying FENG
1
;
Xiang-lan MO
;
Chun-Kui SHAO
;
Zu-lan SU
Author Information
- Publication Type:Journal Article
- MeSH: Female; Gene Expression Regulation, Neoplastic; Herpesvirus 4, Human; physiology; Humans; Lymphoma, T-Cell; genetics; pathology; virology; Male; Matrix Metalloproteinase 9; metabolism; Mucous Membrane; pathology; virology; Natural Killer T-Cells; pathology; virology
- From: Journal of Southern Medical University 2007;27(9):1338-1340
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of matrix metalloproteinase 9 (MMP9) in mucosal natural killer/T cell and mature T cell lymphomas and its relation to Epstein-Barr virus (EBV) infection.
METHODSThe expression of MMP9 and EBV-encoded RNA (EBER) were detected by immunohistochemistry and in situ hybridization in 59 cases of mucosal natural killer/T cell and mature T cell lymphomas.
RESULTSThe positivity rates of MMP9 and EBERs were 83.05% and 72.88% respectively. The positivity rate of EBERs was correlated with histopathological subtype (P<0.05), but not with clinical stage, vascular invasion or the patients' survival time (P>0.05). The expression level of MMP9 was not correlated with the clinical stage, vascular invasion or survival time (P>0.05). No significant correlation was found between MMP9 expression and EBV infection.
CONCLUSIONEBV may play an important role in the development of mucosal natural killer/T cell and mature T cell lymphomas and promote disease progression by up-regulating MMP9 expression indirectly. Elimination of EBV infection may be helpful to prevent the development of lymphoma.
