Effects of Chinese herbal medicine for supplementing Shen and strengthening the bone on rat distal femur cancellous bone in simulated weightlessness: an observation with scanning electron microscope.
- Author:
Ping SUN
1
;
Zhen HUANG
;
De-hong CAI
;
Lei HE
;
Chang-xing WU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drugs, Chinese Herbal; pharmacology; Femur; drug effects; physiology; ultrastructure; Kidney; drug effects; Male; Microscopy, Electron, Scanning; Rats; Rats, Sprague-Dawley; Weightlessness Simulation
- From: Journal of Southern Medical University 2007;27(9):1458-1460
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Chinese herbal medicine for supplementing Shen and strengthening the bone on distal femoral trabecular ultrastructure of male rats subjected to simulated weightlessness.
METHODSFifteen male SD rats were randomized equally into 3 groups, including a control group (group A, in which the rats were allowed free movement) and two simulated weightlessness (via tail suspension) groups (group B and C). The rats in group C were treated with the commercially available Chinese herbal preparation, and those in the other two groups received normal saline at the same dose, for a treatment course of 28 days. Observation of trabeculae was performed with scanning electron microscopy.
RESULTSIn group B, the trabeculae of the femur became thinner, fragile, discontinuous with reduced quantity as compared with those in group A. The rats in group C had greater number of the trabeculae than those in group B. Resorption surface decreased and the collagenous fiber were much more regular in group B.
CONCLUSIONThe Chinese herbal medicine may produce beneficial effect on bone microstructure of rats subjected to simulated weightlessness.
