Acute toxicity of carbon-coated iron nanocrystal and its effect on liver and kidney functions and hematological system.
- Author:
Xiang-Ming LAO
1
;
Hai-Yan ZHANG
;
Jin-Qing LI
;
Yi-Ming CHEN
;
Min-Shan CHEN
;
Yun-Fei YUAN
;
Ya-Qi ZHANG
;
Yun ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Chemical Analysis; Carbon; toxicity; Iron; administration & dosage; toxicity; Kidney; drug effects; physiopathology; Liver; drug effects; physiopathology; Male; Mice; Mice, Inbred BALB C; Nanoparticles; administration & dosage; toxicity; Rats; Rats, Sprague-Dawley
- From: Journal of Southern Medical University 2007;27(10):1471-1475
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the acute toxicity of carbon-coated iron nanocrystal (CCIN) in mice and its effects on hepatic, renal and hematological functions.
METHODSAcute toxicity of CCIN was evaluated by observing the toxic reactions in mice within 14 days following intravenous injection of different doses of CCIN particles. The liver and kidney functions and blood chemistry were tested in rats before and at different time points after CCIN injection.
RESULTSThe median lethal dose (LD(50)) of CCIN particles given by intravenous injection was 203.8 mg /kg in mice. Within the intravenous dose of 80 mg /kg injection, CCIN caused only mild alterations of the rats' biochemical and hematological indices that recovered without intervention in two weeks.
CONCLUSIONCCIN is characterized by low acute toxicity and mild side effects on the hepatic, renal and hematological functions within a certain dose range.
