Expression of vascular endothelial growth factor and metastin in colorectal carcinoma.
- Author:
Qi-Lian LIANG
1
;
Xiao-Dong CHEN
;
San-Ming WANG
;
Jian-Wen LI
;
Bing HUANG
;
Yan-Yun XU
;
Xue-Song CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Colorectal Neoplasms; genetics; metabolism; pathology; Female; Gene Expression Regulation, Neoplastic; Humans; Kisspeptins; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Tumor Suppressor Proteins; genetics; metabolism; Vascular Endothelial Growth Factor A; genetics; metabolism; Young Adult
- From: Journal of Southern Medical University 2007;27(10):1584-1587
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of vascular endothelial growth factor (VEGF) and metastin in colorectal carcinoma and their association with the clinicopathological features of the malignancy.
METHODSVEGF and metastin expressions were examined immunohistochemically with SP method in 70 specimens of human colorectal carcinoma tissues and adjacent normal tissues.
RESULTSVEGF protein overexpression was detected in 48.6% (34/70)of the colorectal carcinoma tissues but in none of the adjacent normal tissues (P<0.01), and for metastin, the overexpression rate was 28.6% (20/70) in the colorectal carcinoma tissues and 70.0% (49/70) in the normal tissues (P<0.01). The expression of both VEGF and metastin was related to the histological grades, infiltration depth, TNM stage and lymph node metastasis of the tumor (P<0.01 and P<0.05, respectively).
CONCLUSIONImmunohistochemical detection of VEGF and metastin can be of value in assessment of the malignancy and in prognostic evaluation of colorectal carcinoma.
