Expression of C-erb B-2 and its relation to angiogenesis in nasopharyngeal carcinoma.
- Author:
Yi-Min LIU
1
;
Guang-Wei YANG
;
Shou-Min BAI
;
Hai-Gang LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma; blood supply; genetics; metabolism; pathology; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; blood supply; genetics; metabolism; pathology; Neovascularization, Pathologic; Receptor, ErbB-2; genetics; metabolism; Vascular Endothelial Growth Factor A; genetics; metabolism; Young Adult
- From: Journal of Southern Medical University 2007;27(10):1588-1589
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of C-erb B-2 expression with angiogenesis in nasopharygeal carcinoma.
METHODSSeventy-seven specimens of nasopharygeal carcinoma were examined immunohistochemically for protein expressions of C-erb B-2 and vascular endothelial growth factor (VEGF), and the microvessel density (MVD) was determined by immunostaining of the endothelial cells for factor VIII-related antigen (F8).
RESULTSPositive C-erb B-2 immunostaining was observed in 36.36% (28/77) of the nasopharygeal carcinoma tissues, which had a VEGF positivity rate of 32.48% (25/77). High positivity rate of C-erg B-2 was associated with high positivity rate of VEGF and high MVD (P<0.05).
CONCLUSIONThe expression of C-erb B-2 may contribute to angiogenesis in nasopharygeal carcinoma.
