Expression of B7-H1 on peripheral blood mononuclear cells from chronic hepatitis B patients.
- Author:
Zhun-yi XIE
1
;
Yong-wen CHEN
;
Xiao-lan FU
;
Cheng-ying YANG
;
Yu-zhang WU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antigens, CD; metabolism; B-Lymphocytes; immunology; B7-H1 Antigen; Case-Control Studies; Female; Hepatitis B, Chronic; immunology; metabolism; Humans; Leukocytes, Mononuclear; metabolism; Male; Middle Aged; Monocytes; immunology; T-Lymphocytes; immunology; Young Adult
- From: Journal of Southern Medical University 2007;27(11):1635-1637
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of B7-H1 on peripheral blood mononuclear cells from patients with chronic HBV infection.
METHODSImmunofluorescent staining and flow cytometry assay were used to measure the expression of B7-H1 on peripheral blood CD3high T cells, CD19high B cells and CD14high monocytes from chronic HBV infected patients.
RESULTSNo significant difference was observed in B7-H1 expression on T cells and B cells between chronic HBV infected patients (CHB) and health controls (HC). B7-H1-expressing CD14high cells were significantly increased in chronic HBV-infected patients (19.17-/+11.64)% as compared with healthy controls [(7.30-/+5.49)%, P<0.01]. A significant positive correlation was found between B7-H1 expression on CD14high monocytes and serum ALT levels.
CONCLUSIONThere is no significant difference in B7-H1 expression on T cells and B cells between CHB patients and healthy subjects. B7-H1, which is up-regulated on monocytes from chronic HBV-infected patients, in positively correlated to serum ALT levels, and may play a role in the persistence of HBV infection.
