The rabbit experimental study for toxicokinetics of chlorpyrifos impacted by hemoperfusion.
- Author:
Xiang GUO
1
;
Xiao CHEN
;
Hongshun ZHANG
;
Xin LONG
;
Qian HE
;
Chengye SUN
;
Xianqing HUANG
;
Jian HE
2
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chlorpyrifos; pharmacokinetics; toxicity; Hemoperfusion; Metabolic Clearance Rate; Rabbits; Toxicokinetics
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2015;33(11):844-846
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate toxicokinetic parameters impacted by hemoperfusion after oral chlorpyrifos exposure, to investigate the adsorption effect of hemoperhusion for chlorpyrifos poisoning.
METHODS12 rabbits were divided into two groups after oral exposure with chlorpyrifos 300 mg/kg body weight. Control group: without hemoperfusion; hemoperfusion group: hemoperfusion starts 0.5 h after chlorpyrifos exposure and lasts for 2h. Blood samples were collected at different times, concentrations of chlorpyrifos were tested by GC, then, toxicokinetic parameterswere calculated and analysis by DAS3.0.
RESULTSIn hemoperfusion group, peak time was (7.19±3.74) h, peak concentrations was (1.37±0.56) mg/L, clearance rate was (13.93±10.27) L/h/kg, apparent volume of distribution was (418.18±147.15) L/kg The difference of these parameter were statistically significant compared with control group (P<0.05).
CONCLUSIONHmoperfusion will decrease the inner exposure and load dose of rabbits with chlorpyrifos poisoning.
