Establishment of a pig model of chronic ally enhanced external counterpulsation.
- Author:
Xiao-lin CHEN
1
;
Xiao-hong HE
;
Yan ZHANG
;
Yue-tao QIAN
;
Lu-guang LIANG
;
Dian-qiu FANG
;
Cheng-yang ZHAN
;
Zhen-sheng ZHENG
;
Hong MA
Author Information
- Publication Type:Journal Article
- MeSH: Anesthesia, General; methods; Animals; Animals, Newborn; Assisted Circulation; Counterpulsation; methods; Models, Animal; Pentobarbital; administration & dosage; Swine
- From: Journal of Southern Medical University 2006;26(5):613-614
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish a pig model of chronic external counterpulsation.
METHODSTwelve pigs were anaesthetized with sodium pentobarbital (< or =30 mg/kg.b.w.) and 846 mixture (< or =0.1 ml/kg.b.w.) and counterpulsed in a lateral position for 2 h every two days (totally 36 h) with 0.025 to 0.04 MPa/cm(2) pressure.
RESULTSExternal counterpulsation was successfully completed in all the animals. Combined administration of sodium pentobarbital and 846 mixture resulted in good anesthetic effect with reduced anesthetic dosage and minimal side effect on the viscera (the liver, kidney and heart, etc).
CONCLUSIONThe pig model of chronic external counterpulsation has been successfully established. Combined use of sodium pentobarbital and 846 mixture is recommended for chronic external counterpulsation.
