Sodium transport of alveolar type II cells in oleic acid-induced acute respiratory distress syndrome.
- Author:
Tao-ping LI
1
;
Hai-yan SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Animals; Ion Transport; Lung Diseases; chemically induced; metabolism; physiopathology; Male; Membrane Potentials; Oleic Acid; Patch-Clamp Techniques; Pulmonary Alveoli; metabolism; pathology; physiopathology; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium; metabolism; Sodium Channels; physiology; Syndrome
- From: Journal of Southern Medical University 2006;26(5):615-616
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the changes of sodium transport of alveolar type II cells in oleic acid-induced acute respiratory distress syndrome (ARDS).
METHODSAfter isolation of the AT II cells as ARDS model induced by oleic acid, the whole cell sodium current was recorded in 5 h with patch-clamp in whole-cell mode. The effect of beta2-agonist terbutaline on the current was also examined.
RESULTSThe sodium currents recorded from AT II cells in ARDS were smaller than that of the control cells, but the current could be stimulated to increase obviously by terbutaline.
CONCLUSIONAT II cells can actively transport sodium ion even under conditions of ARDS, but this capacity can not match that of the control cells. Terbutaline can obviously stimulate the sodium current.
