Quantitative study of dynamic magnetic resonance perfusion-weighted imaging in rabbit models of implanted hepatic VX2 tumor.
- Author:
Xian-yue QUAN
1
;
Xue-lin ZHANG
;
Xi-jie SUN
;
Hai-fang XING
;
Wen LIANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Contrast Media; administration & dosage; Female; Image Interpretation, Computer-Assisted; methods; Liver Neoplasms, Experimental; diagnosis; Magnetic Resonance Angiography; methods; Male; Rabbits; Random Allocation
- From: Journal of Southern Medical University 2006;26(5):620-622
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the possibility of dynamic magnetic resonance (MR) perfusion-weighted imaging (PWI) in rabbit models of implanted hepatic VX2 tumor.
METHODSMRI and PWI images were obtained from 16 rabbit models of implanted hepatic VX2 tumor and 4 normal rabbits at 14, 18, 22, and 26 days after tumor implantation, respectively, and the mean time to enhancement (MTE) and maximum slope of increase (MSI) were estimated and compared with pathological changes.
RESULTSIn the rabbit models of implanted hepatic tumor the MTE tended to increase and MSI to descend 14, 18, 22, and 26 days after tumor implantation, showing significant differences from the control group. Coagulation necrosis and fibrous hyperplasia in the tumors appeared to progress with time as found pathologically.
CONCLUSIONDynamic MR PWI quantitative analysis of rabbit models of implanted hepatic VX2 tumor provides valuable means for observing the growth behaviors of VX2 tumor and may be clinically applicable in the evaluation of hepatic diseases.
