Expression of aquaporin-1 in a guinea pig model of labyrinth destruction.
- Author:
Qi LI
1
;
De-liang HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aquaporin 1; biosynthesis; Cochlea; metabolism; pathology; Disease Models, Animal; Endolymphatic Sac; metabolism; pathology; Female; Guinea Pigs; Immunohistochemistry; Labyrinth Diseases; metabolism; Male
- From: Journal of Southern Medical University 2006;26(5):664-666
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of aquaporin-1(AQP-1) in the cochlea and endolymphatic sac in guinea pigs with labyrinth destruction.
METHODSChloroform was injected into the tympanum to establish the animal model of labyrinth destruction in guinea pigs, and two-step immunohistochemical method was used to examine the expression of AQP-1 in the cochlea and endolymphatic sac at different time points.
RESULTSAQP-1 expression was fluctuant in accordance with the morphological changes of the spiral ligament fibrocytes in the cochlea: destruction of the spiral ligament cells was followed by AQP-1 expression down-regulation, and AQP-1 up-regulation occurred with the cell regeneration. But no such changes were observed in the endolymphatic sac.
CONCLUSIONAQP-1 may take part in the maintenance of the structural stability of the spiral ligament.
