Expression of TGFbeta1 and its type I receptors ALK1 and ALK5 mRNA in brain arteriovenous malformation.
- Author:
Guang-zhong CHEN
1
;
Tie-lin LI
;
Wei QUAN
;
Tao HUANG
;
Qing-ping ZHAO
;
Jian-qi WANG
;
Chuan-zhi DUAN
;
Qiu-jing WANG
;
Xiao-dan JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Activin Receptors, Type II; genetics; Adolescent; Adult; Brain; metabolism; pathology; Female; Gene Expression; Humans; Intracranial Arteriovenous Malformations; genetics; Male; Middle Aged; Protein-Serine-Threonine Kinases; genetics; RNA, Messenger; biosynthesis; genetics; Receptors, Transforming Growth Factor beta; genetics; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta1; genetics
- From: Journal of Southern Medical University 2006;26(5):675-677
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expression of transforming growth factor beta1 (TGFbeta1) and its type I receptors activin-like kinase 1 (ALK1) and ALK5 mRNA in the development of brain arteriovenous malformation (BAVM).
METHODSThe mRNA expressions of TGFbeta1, ALK1and ALK5 were detected with semiquantitative RT-PCR in patients with BAVM.
RESULTSThe expressions of TGFbeta1 and ALK5 mRNA increased significantly in BAVM, and their relative expression quantity were 0.777-/+0.047 and 0.585-/+0.074, respectively. However, ALK1 mRNA expression declined significantlies with a relative expression of 0.173-/+0.044 in comparison with the control group (0.720-/+0.098, P<0.01).
CONCLUSIONThe balance of TGFbeta1 and its type I receptors ALK1 and ALK5 mRNA expressions may play important role in the development of BAVM.
