Expression of tissue inhibitor of metalloproteinase-1 in colorectal carcinoma and its clinical implications.
- Author:
Yang LIU
1
;
Bo JIANG
;
Hua-sheng TONG
;
Xiao-rong LAI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Colorectal Neoplasms; metabolism; pathology; Epithelial Cells; chemistry; pathology; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Middle Aged; Tissue Inhibitor of Metalloproteinase-1; biosynthesis
- From: Journal of Southern Medical University 2006;26(5):699-700
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression and clinical implication of tissue inhibitor of metalloproteinase-1 (TIMP-1) in colorectal carcinoma.
METHODSTIMP-1 expression in 54 colorectal carcinoma was observed by SP immunohistochemical method, and the results were analyzed in relation to the clinical data of patients.
RESULTSTIMP-1 was localized on the membrane and in the cytoplasm of the enteric epithelial cells, and its expression rate was 100% in normal tissue but only 59.6% (31/52) in colorectal carcinoma tissues. In addition, the expression rate of TIMP-1 was higher in the tumor tissues without lymph node metastasis than in tissues with lymph node metastasis (P<0.05).
CONCLUSIONThe expression of TIMP-1 is inversely correlated to lymph node metastasis of colorectal carcinoma, and decreased TIMP-1 expression may play a role in the progression of colorectal carcinoma.
