Effects of the HLA antibodies on allograft acute rejection after cadaveric liver transplantation.
- Author:
Wei CHEN
1
;
Gui-hua CHEN
;
Min-qiang LU
;
Yang YANG
;
Chang-jie CAI
;
Bao-hua HOU
;
Ye LIN
;
Wei-dong ZHANG
;
Lu-lu XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antibodies; blood; Female; Graft Rejection; immunology; HLA Antigens; immunology; Humans; Isoantibodies; blood; Liver Cirrhosis; surgery; Liver Neoplasms; surgery; Liver Transplantation; immunology; methods; Male; Middle Aged
- From: Journal of Southern Medical University 2006;26(6):774-776
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of perioperative HLA antibody changes on acute allograft rejection in cadaveric liver transplantation.
METHODSTotally 134 patients received modified piggyback liver transplantation and enzyme-linked immunosorbent assay was performed for HLA antibody detection before and the 1, 7, 14 and 30 days after operation. B ultrasound-guided liver biopsy was employed for diagnosis of acute allograft rejection, and the perioperative changes of HLA antibodies were evaluated for their effect on allograft acute rejection.
RESULTSOf the 44 recipients with preoperative positivity for HLA antibodies, acute rejection occurred in 56.8% of the patients, as compared with 25.9% in those negative for HLA antibody (P=0.001). The patients who became positive for HLA antibody postoperatively had a rate of acute rejection of 60%, which was significantly higher than that in those persistently negative for HLA antibody (18.6%, P=0.003).
CONCLUSIONHLA antibody positivity before transplantation may contribute to acute rejection episode in liver transplantation, and persistent posttransplant HLA antibody positivity is closely associated with the occurrence of acute rejection.
