Oncogene ZNF217 amplification on chromosome 20 q in ovarian serous cystadenocarcinoma and its clinical implications.
- Author:
Jing LI
1
;
Mei ZHONG
;
Lan-lin SONG
;
Gui-dong SU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Chromosomes, Human, Pair 20; genetics; Cystadenocarcinoma, Serous; genetics; pathology; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization, Fluorescence; Middle Aged; Ovarian Neoplasms; genetics; pathology; Prognosis; Trans-Activators; genetics
- From: Journal of Southern Medical University 2006;26(6):824-825
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the amplification of zinc finger protein 217 (ZNF217) gene on chromosome 20 in ovarian cancer and its clinical significance.
METHODSTwenty-three specimens of ovarian carcinoma (11 cases of early stage and 12 advanced stage), 10 specimens of benign ovarian tumors and 7 normal ovaries were examined for ZNF217 gene amplification on chromosome 20 by fluorescence in situ hybridization (FISH).
RESULTSZNF217 gene amplification was detected in 12 cases of ovarian cancer (52.17%) and 1 case of benign ovarian tumor, but not in normal ovary. ZNF217 amplification was significantly associated with ovarian cancer.
CONCLUSIONOncogene ZNF217 is associated with the tumor stage and poor prognosis of patients with ovarian cancer.
