Role of the cut-off value of serum neuron-specific enolase in differentiating small cell lung cancer from non-small cell lung cancer.
- Author:
Tao WEI
1
;
Rong-cheng LUO
;
Qiang ZUO
;
Jun-yi ZHANG
;
Jing-xia MIAO
;
Hui-fang LU
Author Information
- Publication Type:Journal Article
- MeSH: Biomarkers, Tumor; blood; Carcinoma, Non-Small-Cell Lung; enzymology; pathology; Carcinoma, Small Cell; enzymology; pathology; Diagnosis, Differential; Female; Humans; Lung Neoplasms; enzymology; pathology; Male; Middle Aged; Phosphopyruvate Hydratase; blood
- From: Journal of Southern Medical University 2006;26(6):858-859
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the cut-off value of serum neuron-specific enolase (NSE) level for distinguishing small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC).
METHODSSerum NSE levels were measured by enzyme-linked immunosorbent assay in 137 patients with NSCLC or SCLC, and the best cut-off value was analyzed using ROC curve.
RESULTSThe positivity rate of serum NSE was significantly higher in patients with SCLC than in those with NSCLC (P<0.01). The best cut-off value was 15.45 microg/L using ROC curve, which gave a sensitivity of 66.7% and specificity of 65.7%.
CONCLUSIONSerum NSE level may allow simple and cost-effective differentiation of SCLC and NSCLC.
