Expression of Ki-67 and Bcl-2 in adults and children with acute lymphoblastic leukemia and its clinical significance.
- Author:
Wei XU
1
;
Jian-Yong LI
;
Yu-Jie WU
;
Rui-Lan SHENG
;
Feng-Xiang LU
Author Information
1. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. xuwei10000@hotmail.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Antineoplastic Combined Chemotherapy Protocols;
therapeutic use;
Apoptosis;
physiology;
Child;
Child, Preschool;
Female;
Humans;
Ki-67 Antigen;
biosynthesis;
Male;
Middle Aged;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
drug therapy;
metabolism;
pathology;
Proto-Oncogene Proteins c-bcl-2;
biosynthesis
- From:
Journal of Experimental Hematology
2006;14(5):887-890
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the expressions of proliferative antigen Ki-67 and apoptosis-antagonizing protein Bcl-2 as well as their clinical significance, immunohistochemistry staining with SAP was used to detect Ki-67 antigen and Bcl-2 protein in 18 cases of children with acute lymphoblastic leukemia (ALL) and 43 cases of adults with ALL. The results showed that the levels of Ki-67 and Bcl-2 expression in children with ALL were lower than that in adults, but only Bcl-2 expression had significant difference. Both in children and in adults, the levels of Ki-67 expression in T-ALL and My(+) ALL were higher than that in B-ALL and null-ALL. The highest complete remission rate (CR) was seen in the group with lower expression of both indexes (Ki-67 and Bcl-2). The lowest CR rate was seen in the group with higher expression of both indexes. It is concluded that the levels of Ki-67 and Bcl-2 expression in children and adults with ALL were closely related with the subtype of ALL and chemotherapeutic effects.
