Trehalose -- a biomembrane protectant applied to lyophilization of human red blood cells: review.
- Author:
Yuan ZHUANG
1
;
Jing-Han LIU
Author Information
1. Department of Blood Transfusion, General Hospital of PLA, Military Clinical Transfusion Research Center, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
Blood Preservation;
methods;
Cryoprotective Agents;
pharmacology;
Erythrocytes;
cytology;
drug effects;
Freeze Drying;
Humans;
Trehalose;
pharmacology
- From:
Journal of Experimental Hematology
2006;14(5):1061-1064
- CountryChina
- Language:Chinese
-
Abstract:
Trehalose, as a nonreducing disaccharide, plays a role in protecting the cytoactivity when the cells is freezing, drying or lyophilization. It has been a biomembrane protectant applied to lyophilization of human blood cells (platelets and erythrocytes), and from which astonishing results have been obtained. Having powerful hydration, distinctive vitrification transform and crystal transform and unique resistance of high temperature and humidification, trehalose is thought of a preferred protectant in the study of cell preservation. In recent years, people concerned trehalose on its protective mechanism, experimental means of transit trehalose to mammal cells and the mechanism of loading in red blood cells. The above aspects were briefly summarized in this article.
