Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia.
- Author:
A-Mei CHEN
1
;
Xiao-Ming GUO
;
Wen-Ying YAN
;
Song-Mei XIE
;
Na ZHU
;
Xin-Dang WANG
;
Ri XU
;
Qing-Ping LIU
Author Information
1. Department of Histology and Embryology, Inner Monglia Medical College, Huhhot 010059, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Child, Preschool;
Female;
Genetic Predisposition to Disease;
genetics;
Genotype;
Humans;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
genetics;
Male;
Middle Aged;
Polymorphism, Genetic;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
genetics;
Receptors, Immunologic;
genetics;
Receptors, KIR;
Receptors, KIR2DL1;
Receptors, KIR2DL3;
Receptors, KIR2DL4;
Receptors, KIR3DL1;
Receptors, KIR3DL2;
Receptors, KIR3DS1
- From:
Journal of Experimental Hematology
2007;15(1):35-38
- CountryChina
- Language:Chinese
-
Abstract:
The study was purposed to investigate the polymorphism of killer cell immunoglobulin-like receptor (KIR) gene of the patients with leukemia and to explore the correlation between the KIR gene and susceptibility of leukemia. The KIR genotype of 50 patients with leukemia and 60 healthy controls in northern. Hans were analyzed by PCR-SSP. The results indicated that the present known 18 KIR genes were detected and identified. The frequencies of KIR 3DL3, 3DL2 and 2DL4 were 100% in all subjects, with the most frequent genotype KIR 3DP1 (0.86) followed by 2DP1, 2DL3, 3DL1, 2DL1, 3DS1, 2DL5, 2DS4, 2DS2, 1D, 2DS5, 2DL2, 2DS1, 2DS3 and 3DP1v in leukemia successively. Compared with the control, the KIR 3DL1 (0.60) and 2DL1 (0.57) were significantly lower in the leukemia patient group than that in the control group (1.00) (P < 0.01). It is concluded that the polymorphism of KIR gene is associated with susceptibility of leukemia in Hans. There may be a negative correlation between pathogenesis of leukemia and KIR 3DL1, KIR 3DS1, KIR 2DL1, KIR 2DL5 genes.
