Efficacy of hypofractionated radiotherapy combined with docetaxel for treatment of bone metastasis of lung cancer.
- Author:
Zheng-Fu FENG
1
;
Xin LIU
;
Zhuo-Mei LIU
;
Hui-Sheng SONG
;
Rui-Ming TANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Bone Neoplasms; drug therapy; radiotherapy; secondary; Combined Modality Therapy; Dose Fractionation; Female; Humans; Lung Neoplasms; drug therapy; pathology; radiotherapy; Male; Middle Aged; Prognosis; Taxoids; therapeutic use; Treatment Outcome
- From: Journal of Southern Medical University 2009;29(7):1442-1444
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy of hypofractionated radiotherapy combined with docetaxel for treatment of bone metastasis of lung cancer and explore the factors related to the prognosis.
METHODSSeventy-two patients with bone metastasis of lung cancer were divided into group A with hypofractionated radiotherapy at 3.0 Gy /fraction (once a day, 5 days per week for 30 Gy) and weekly docetaxel treatment at 60 mg for 2 weeks, and group B with radiotherapy alone at 2.0 Gy/fraction (once a day, 5 days per week for 40 Gy).
RESULTSThe total effective rate was 93.1% (67/72) in these patients, with a non-response rate of 6.9% (5/72). The total effective rate was 97.2% (35/36) in group A and 88.9% (32/36) in group B. After the radiotherapy, the analgesic effect showed no significant difference between the two groups, but the onset of the effect was faster in group B than in group A.
CONCLUSIONLocal radiotherapy provides effective pain relief in patients with bone metastasis of lung cancer. High-dose fractionated irradiation can rapidly achieve the analgesic effect.
