Expression of fragile histidine triad in endometriosis.
- Author:
Gui-Dong SU
1
;
Yan KE
;
Yan-Hong YU
;
Guang-Liang ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Acid Anhydride Hydrolases; metabolism; Adult; Endometriosis; metabolism; pathology; Endometrium; metabolism; Female; Humans; Middle Aged; Neoplasm Proteins; metabolism
- From: Journal of Southern Medical University 2009;29(7):1479-1481
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the expression of fragile histidine triad in endometriosis and investigate the pathogenesis of endometriosis.
METHODSimmunohistochemistry was used to examine the expression of Fhit in the eutopic and ectopic endometria of 58 patients with endometriosis and in the endometria in 15 patients with hysteromyoma.
RESULTSThe intensity of Fhit expression decreased in the order of normal endometrium, eutopic endometrium in endometriosis group, and ectopic endometrium. In patients with endometriosis, Fhit expression in the eutopic and ectopic endometria in proliferative phase showed no significant difference from that in secretory phase (P>0.05). Fhit expression in the ectopic endometrium showed significant difference between different r-AFS stages. MOD of ectopic endometrium in stages I-II was significantly higher than that in stages III-IV (P<0.05), but Fhit expression in the eutopic endometrium showed no significant difference (P>0.05). MOD of ovarian endometriosis showed no difference with that of adenomyosis.
CONCLUSIONSFhit may play an important role in the development of endometriosis.