Effect of modified Yupingfeng granule on nuclear factor-kappaB expression in mice with allergic contact dermatitis.
- Author:
Li LI
1
;
Liu-ping LIANG
;
Gui-rong HOU
;
Ren LUO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Dermatitis, Allergic Contact; drug therapy; metabolism; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; administration & dosage; pharmacology; therapeutic use; Gene Expression Regulation; drug effects; Mice; Mice, Inbred BALB C; NF-kappa B; metabolism
- From: Journal of Southern Medical University 2009;29(8):1582-1584
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of modified Yupingfeng granule on nuclear factor-kappaB (NF-kappaB)expression in mice with allergic contact dermatitis (ACD).
METHODSMouse models of ACD were treated with the granules at low, medium and high doses, with normal saline and hydrocortisone as the negative and positive controls, respectively. The expressions of NF-kappaB and its distribution in the lesions were detected using immunohistochemistry.
RESULTSThe staining intensity, area and positive expression rates of NF-kappaB p50 were significantly different between the treatment group and the normal saline group (P<0.05).
CONCLUSIONModified Yupingfeng granule can effectively inhibit the expression of NF-kappaB in ACD, which might be a possible mechanism for its therapeutic effect on ACD.
