Effect of immunonanoparticles loaded with adriamycin on multidrug-resistant liver cancer in nude mice.
- Author:
He-ping KAN
1
;
Yu WANG
;
Yong-fa TAN
;
Jie ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Line, Tumor; Doxorubicin; chemistry; metabolism; pharmacology; therapeutic use; Drug Resistance, Multiple; drug effects; Drug Resistance, Neoplasm; drug effects; Female; Humans; Immunoconjugates; chemistry; Liver Neoplasms; drug therapy; metabolism; pathology; Mice; Mice, Nude; Nanoparticles; chemistry
- From: Journal of Southern Medical University 2009;29(8):1617-1619
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of the immunonanoparticles loaded with adriamycin in reversing multidrug resistance (MDR) in liver cancer in a nude mouse model and explore the possible mechanisms.
METHODSThe cytotoxicity of adriamycin, adriamycin-loaded nanoparticles, and adriamycin-loaded immunonanoparticles was assessed in a nude mouse model bearing implant tumors of adriamycin-resistant hepatoma cell line SMMC-7721/ADM. The concentration of adriamycin in the tumor tissue was determined.
RESULTSAdriamycin-loaded immunonanoparticles showed significantly stronger cytotoxicity against the implant tumors of SMMC-7721/ADM than adriamycin-loaded nanoparticles and adriamycin. Administration of adriamycin-loaded immunonanoparticles resulted in significantly higher drug concentrations in the tumor tissue than adriamycin-loaded nanoparticles and adriamycin.
CONCLUSIONAdriamycin-loaded immunonanoparticles may reverse the MDR of liver cancers in vivo probably resulting from the close binding of the particles with the tumor cells to produce a high local concentration of adriamycin in the tumors.
