Laparoscopy combined with endoscopic and digital subtraction angiography for treatment of severe acute pancreatitis.
- Author:
Hao LIU
1
;
Kai-yun CHEN
;
Guo-an XIANG
;
Han-ning WANG
;
Fang-lian XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Angiography, Digital Subtraction; Endoscopy, Digestive System; Female; Humans; Interleukin-1beta; blood; Kidney; physiopathology; Laparoscopy; Liver; physiopathology; Male; Middle Aged; Multiple Organ Failure; Pancreatitis; blood; diagnostic imaging; pathology; surgery; Treatment Outcome; Tumor Necrosis Factor-alpha; blood
- From: Journal of Southern Medical University 2009;29(8):1620-1622
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of laparoscopy combined with endoscopic and digital subtraction angiography in the treatment of severe acute pancreatitis (SAP).
METHODSNine-seven SAP patients were randomly divided into group A (n=32) with conventional treatment and group B (n=35) with combined treatment with laparoscopy, endoscopic and digital subtraction angiography in addition to the conventional treatment. The clinical indices and therapeutic effects in the 2 groups were compared.
RESULTSAfter treatment, the patients in group B had significantly lower APACHE score than those in group A (P<0.05), with also better hepatic, renal and lung functions (P<0.05). The serum TNF-alpha and IL-1beta levels was significantly lower, but IL-10 significantly higher in group B (P<0.05). The CT SPN was significantly lowered in group B as compared with that in group A (P<0.05). The patients in group B had significantly lower rate of organ failure (P<0.01) and higher successful rate in organ failure management (P<0.05), with also lowered inhospital mortality than those in group A (P<0.05).
CONCLUSIONLaparoscopy combined with endoscopic pancreaticobiliary duct drainage and digital subtraction angiography in addition to conventional treatment significantly improves the outcome and decreases the mortality of SAP patients.
