Expression of aquaporin-1 in human oligohydramnios placenta and fetal membranes.
- Author:
Rong-Zeng HAO
1
;
Hui-Shu LIU
;
Zheng-Fang XIONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aquaporin 1; genetics; metabolism; Extraembryonic Membranes; metabolism; Female; Humans; Oligohydramnios; metabolism; Placenta; metabolism; Pregnancy; Pregnancy Trimester, Third; RNA, Messenger; genetics; metabolism; Young Adult
- From: Journal of Southern Medical University 2009;29(6):1130-1132
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect aquaporin-1 mRNA (AQP1) expression in human oligohydramnios placenta and fetal membranes.
METHODSPlacenta and fetal membranes samples were obtained from 5 women with oligohydramnios and 5 with normal amniotic fluid volume. AQP-1 mRNA expression in the tissue samples was detected by semi-quantitative RT-PCR.
RESULTSThe expression of AQP1 mRNA was significantly lower in oligohydramnios placenta than in normal pregnancy placenta at term (P<0.05), and also significantly lower in oligohydramnios fetal membranes than in normal fetal membranes at term (P<0.05).
CONCLUSIONAlterations in AQP1 mRNA expressions in human placenta and fetal membranes may play an important role in the disorder of maternal-fetal fluid exchange and amniotic fluid volume.
