Multivariate analysis of the risk factors of cytomegalovirus pneumonia after renal transplantation.
- Author:
Qiang WEI
1
;
Li-Xin YU
;
Wen-Feng DENG
;
Jun-Sheng YE
Author Information
- Publication Type:Journal Article
- MeSH: Age Factors; Aged; Cytomegalovirus Infections; etiology; prevention & control; Female; Graft Rejection; Humans; Kidney Transplantation; adverse effects; Male; Middle Aged; Multivariate Analysis; Pneumonia, Viral; etiology; prevention & control; Postoperative Complications; etiology; prevention & control; Renal Dialysis; Retrospective Studies; Risk Factors
- From: Journal of Southern Medical University 2009;29(6):1182-1184
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify the risk factors for cytomegalovirus (CMV) pneumonia after renal transplantation and investigate the early precaution measures.
METHODSA retrospective study was conducted in a group of 28 patients undergoing renal transplantation who were readmitted because of CMV pneumonia between Jan, 2005 and Dec, 2007. Chi-square test and multivariate logistic regression were used to identity the significant risk factors.
RESULTSSeven factors, namely recipient age, acute graft rejection, pre-transplantation dialysis, delayed graft function recovery, recipient peak PRA level, donor CMV positivity and the use of MMF were found to significantly correlate to post-transplant CMV pneumonia. Multivariate logistic regression further confirmed that donor CMV IgG positivity, acute graft rejection and pre-transplantation dialysis for over 6 months were independent factors to predict the occurrence of CMV pneumonia.
CONCLUSIONSAcute graft rejection control, appropriate donor selection and shortened dialysis before the transplantation can be crucial factors to reduce the incidence of CMV pneumonia after renal transplantation.
