Change of serum TGF-beta1 and TNF-alpha in silicosis patients.
- Author:
Rong-Ming MIAO
1
;
Xue-Tao ZHANG
;
Yu-Lan YAN
;
En-Qi HE
;
Ping GUO
;
Ying-Yi ZHANG
;
Dao-Kun ZHAO
;
Zhi-Gang YANG
;
Jie CHEN
;
Ming-Ying YAO
;
Rui ZHAO
;
Zhong-Hua FANG
;
Yong-Ming YAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; Humans; Male; Middle Aged; Occupational Exposure; Silicosis; blood; diagnosis; Transforming Growth Factor beta1; blood; Tumor Necrosis Factor-alpha; blood
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2011;29(8):606-607
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe serum TGF-beta1 and TNF-alpha in silicosis patients and workers exposed to silica dust to study the role of TGF-beta1 and TNF-alpha in the development of silicosis.
METHODSOne hundred non-exposed workers were selected as control group, 200 workers exposed to silica dust for more than 1 year as exposed group, 32 suspected silicosis patients (originally diagnosed as 0+) as observing group, 130 silicosis patients were as silicosis group. Serum TGF-beta1 and TNF-alpha in each group were determined with ELISA.
RESULTSSerum TNF-alpha in exposed group [(47.86 +/- 16.52) pg/ml], observing group [(109.11 +/- 31.08) pg/ml], silicosis group [(216.35 +/- 51.03) pg/ml] were significantly higher than that in control group [(6.90 +/- 2.24) pg/ml] (P < 0.01); Silicosis group and observing group were also higher than exposed group (P < 0.01, P < 0.05). Compared with control group [(23.28 +/- 12.24) pg/ml] and exposed group [(29.31 +/- 14.52) pg/ml], serum TGF-beta1 in silicosis group was much higher (P < 0.01).
CONCLUSIONTGF-beta1, and TNF-alpha were essential in the development of silicosis, so the detection of TGF-beta1 and TNF-alpha in peripheral blood was very useful for occupational health surveillance and early diagnosis of silicosis.
