Study on mRNA expression of immune-related genes in patients with allergic dermatitis induced by trichloroethylene.
- Author:
Xin-yun XU
1
;
Yue-feng LIU
;
Juan YI
;
Yue-bin KE
;
Jian-hui YUAN
;
Hai-yan HUANG
;
Ji-yan MAO
;
Kan-langl MAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; CTLA-4 Antigen; metabolism; Case-Control Studies; Dermatitis, Occupational; genetics; immunology; Female; Forkhead Transcription Factors; metabolism; GATA3 Transcription Factor; metabolism; Gene Expression; Humans; Male; RNA, Messenger; genetics; T-Box Domain Proteins; metabolism; Trichloroethylene; Young Adult
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2011;29(11):816-819
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study mRNA expression of immune-related genes (Foxp3, GATA3, CTLA4 and T-bet) in peripheral blood of the patients with allergic dermatitis induced by trichloroethylene (TCE).
METHODSThe peripheral blood samples were collected from 8 healthy workers (control group) and 8 patients with allergic dermatitis induced by TCE (case group). Real-time quantitative PCR was applied to detect mRNA expression of immune-related genes (Foxp3, GATA3, CTLA4, T-bet).
RESULTSThe mRNA expression levels of Foxp3, GATA3 and CTLA4 genes increased by 115%, 97% and 241% in case group, as compared with control group (P < 0.01). The mRNA expression level of T-bet gene decreased by 47% in case group, as compared with control group (P < 0.01).
CONCLUSIONThe mRNA expression levels of some immune-related genes changed in patients with allergic dermatitis induced by TCE, those genes may play an important role in TCE-induced allergy.
