Study on mutagenicity and teratogenicity of ammonium dinitramide.
- Author:
Wen-xia DU
1
;
Yu-ling WANG
;
Yuan-han SUN
;
Feng XIE
;
Zhi-qiang CHANG
;
Ya-fei XING
;
Yan-wei ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Embryo, Mammalian; drug effects; pathology; Female; Male; Mice; Mice, Inbred Strains; Micronucleus Tests; Mutagenicity Tests; Nitrites; toxicity; Pregnancy; Quaternary Ammonium Compounds; toxicity; Spermatozoa; drug effects; pathology; Sternum; drug effects; pathology
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2011;29(11):843-845
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the mutagenicity and teratogenicity induced by ammonium dinitramide(ADN).
METHODSAccording to technical specifications for toxicity determination of chemicals, Salmonella typhimurium reverse mutation assay (Ames assay), in vivo mammalian erythrocyte micronucleus test, sperm malformation test and teratogenesis test were used to detect the mutagenicity and teratogenicity induced by AND.
RESULTSWhen the exposure doses of AND were 8-5000 pg/plate, the result of Ames assay was negative. As compared with control group, the micronucleus rate of mice exposed to 113.8 mg/kg AND significantly increased(P<0.05), the sperm malformation rates of mice exposed to 54.4-272.0 mg/kg AND did not increased significantly. The survival rate of fetuses decreased, the rate of assimilated fetuses increased, the rate of fetus sternum agenesis enhanced in mice exposed to 319 mg/kg AND, as compared with controls. The rates of in the 4th-6th fetus sternum agenesis in groups exposed to 21.3, 79.7 and 319 mg/kg AND were higher than that in control group. The malformation rate of fetus bowels in groups exposed to 319 mg/kg AND was higher than that in control group. The teratogenic index of ADN was 30.
CONCLUSIONAND may be a mutagen and induce the teratogenic effect.
