Effect of sodium ferulate on fluidity and morphology of cell membrane in ozone induced lung injury.
- Author:
De-jun WANG
1
;
Xiao-jun DAI
;
Feng XU
;
Yun SUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Membrane; drug effects; Coumaric Acids; pharmacology; Female; Free Radical Scavengers; pharmacology; Lung; drug effects; metabolism; pathology; Male; Malondialdehyde; analysis; Membrane Fluidity; drug effects; Mice; Mice, Inbred ICR; Ozone; toxicity
- From: Chinese journal of integrative medicine 2006;12(4):297-300
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo study the effect of sodium ferulate (SF), an active component of Radix Angelica, on lung damage induced by ozone (03).
METHODSMice model of lung injury was induced by ozone inhalation and treated with SF. The level of lipid peroxide and microviscosity in alveolar epithelial cell membrane of the mice was determined, and the structural change of lung cells was observed by microscopy.
RESULTSOzone could increase the level of malondialdehyde (MDA) and the microviscosity in alveolar epithelial cell membrane, and induce inflammatory changes in morphologic structure. These abnormal changes were improved after SF administration, which was manifested as alleviation of heightened microviscosity, increase of membrane fluidity, as well as the basically normalized pulmonary cellular structure under microscope.
CONCLUSIONSF has a preventive effect against oxidized pulmonary injury induced by ozone, the action of which could be through scavenging oxygen free radicals, reducing lipid peroxide production, increasing membranous fluidity and mitigating inflammatory changes in cell structure. sodium ferulate, ozone, malondialdehyde, membranous fluidity, morphology
