Association between genetic variations in methylenetetrahydrofolate reductase and risk of colorectal cancer in a Chinese population.
- Author:
Xiao-ping MIAO
1
;
Shen YANG
;
Wen TAN
;
Xue-mei ZHANG
;
Ying-jiang YE
;
Dong-xin LIN
;
Shan WANG
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; China; Colorectal Neoplasms; ethnology; genetics; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Methylenetetrahydrofolate Reductase (NADPH2); genetics; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Risk Factors
- From: Chinese Journal of Preventive Medicine 2005;39(6):409-411
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between genetic variations in methylenetetrahydrofolate reductase (MTHFR) and the risk of colorectal cancer in a Chinese population.
METHODSOne hundred and ninety-eight cases of colorectal cancer and 420 controls were genotyped for detecting MTHFR C677T and A1298C polymorphisms by PCR-RFLP methods. The adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated by using unconditional logistic regression model.
RESULTSThe frequency of the MTHFR C677T allele found among cases was significantly more frequent than that among controls (51.3% to 44.4%, P = 0.02). As compared with the 677CC genotype, the 677TT genotypes had a 67% (95% CI, 1.05 - 2.66) increased risk of colorectal cancers. However, there appeared no any correlations between the genetic variations of MTHFR and the cancer metastasis.
CONCLUSIONThese findings demonstrated that the genetic variation of MTHFR C677T should be a genetic susceptibility factor for colorectal cancer in a Chinese population.
