Effects of extracts of root of kudzu vine on mammary gland and uterus development in rats.
- Author:
Xiao-ou XUE
1
;
Huan JIN
;
Jian-zhao NIU
;
Ji-feng WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drugs, Chinese Herbal; isolation & purification; pharmacology; Estradiol; blood; Female; Follicle Stimulating Hormone; blood; Luteinizing Hormone; blood; Mammary Glands, Animal; anatomy & histology; growth & development; Organ Size; drug effects; Plant Roots; chemistry; Plants, Medicinal; chemistry; Prolactin; blood; Pueraria; chemistry; Rats; Rats, Wistar; Uterus; anatomy & histology; growth & development
- From: China Journal of Chinese Materia Medica 2003;28(6):560-562
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of extracts of root of kudzu vine on mammary gland and uterus development in rats.
METHOD40 Wistar rats weighting 65-85 g were randomly divided into 4 groups: control group, estrogen group, extracts of root of kudzu vine group of high dose, extracts of root of kudzu vine group of low dose. (10 rats in each group). After having been treated for 7 days, the rats were killed; mammary glands and uterus were removed and weighed. Serum was isolated and kept at 4 degrees C for determination of hormones.
RESULT1. Administration of the root of kudzu vine significantly increased the weigh of mammary gland and uterus in rats. 2. Administration of the root of kudzu vine increased serum FSH, LH, E2 and decreased PRL.
CONCLUSIONExtracts of root of kudzu vine could enhance the weight of mammary gland and uterus growth in rats, which may provide experimental evidence for the development of new drug used for promoting mammary gland and uterus.
