Effects of yishenjiangyafang on blood pressure and protecting renal function in RPH rats.
- Author:
Meng-li CHEN
1
;
Wen-jun LIU
;
Cai-yun WANG
;
Xiu-mei ZHU
;
Jian-fen YIN
;
Dong-xiao WANG
;
Ping LIU
Author Information
- Publication Type:Journal Article
- MeSH: Angelica sinensis; chemistry; Animals; Antihypertensive Agents; pharmacology; Astragalus membranaceus; chemistry; Blood Pressure; drug effects; Blood Urea Nitrogen; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Hypertension, Renal; blood; pathology; physiopathology; Kidney; pathology; Male; Paeonia; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2003;28(8):746-751
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects and mechanism of Yishenjiangyafang, a prescription of Chinese traditional herbs used for renal hypertension, on blood pressure and protecting renal function of RPH rats.
METHODThe 5/6 kidney of rat was resected to set up the RPH rat model. Blood pressure, Cr(creatinine), Ccr(creatinine clearance) and BUN(urea nitrogen) were measured dynamically. After eight weeks treatment, plasma content of PAR A II TXB2, 6-keto-PGF1 were measured. At same time, The change of renal pathology was observed.
RESULTYishenjiangyafang could reduce blood pressure Cr, but had no effect on BUN of RPH rat. The indexes of PAR, A II of each different dosage group of Yishenjiangyafang were decreased. At the same time, it reduced plasma content of TXB2, and increased 6-keto-PGF1 alpha. Glomerulosclerosis and atrophy of renal tubule in Yishenjiangyafang group RPH rats were better than those of the contrast group and the Capten group.
CONCLUSIONYishenjiangyafang can reduce blood pressure of RPH rats and has protective effects on its kidney. Yishenjiangyafang can perform its effects of reducing blood pressure and protecting kidney by influencing the RAS of RPH rats.
