Effects of one Chinese herbs on improving cognitive function and memory of Alzheimer's disease mouse models.
- Author:
Hua SUN
1
;
Yu HU
;
Jian-min ZHANG
;
Shi-you LI
;
Wei HE
Author Information
- Publication Type:Journal Article
- MeSH: Acorus; chemistry; Alzheimer Disease; chemically induced; psychology; Animals; Brain; pathology; Cognition; drug effects; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Lycium; chemistry; Male; Mice; Mice, Inbred BALB C; Plants, Medicinal; chemistry; Random Allocation; Retention (Psychology); drug effects
- From: China Journal of Chinese Materia Medica 2003;28(8):751-754
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate Chinese herbs with the effect on significantly improving the cognitive function and retention of patients with Alzheimer's disease.
METHODAD mouse models were established by injecting poly-beta-AP25-35 into the cerebral ventricle of mice. The curative effects of traditional Chinese herbs Dangguishaoyaosan, Chaihujialonggumulitang and two herbs (CHP I and CHP II) developed by the authors on improving the memory and cognitive function of AD mouse models were studied by the detection of behavioral and histochemical tests, with piracetam serving as control.
RESULTCHP II has profound curative effects on improving the memory and cognitive function of AD-like animal model.
CONCLUSIONThe present study indicates that it has a satisfactory prospect to seek new drugs from Chinese herbs to treat AD.
