Effects of yixintong on regulating cellular calcium channels.
- Author:
Si-cheng LI
1
;
Hua HUANG
;
Fei-ming ZHENG
;
De-liang WEN
;
Shang-wu MO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aorta; cytology; Calcium Channels; drug effects; Crataegus; chemistry; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Flavonoids; isolation & purification; pharmacology; Male; Muscle, Smooth, Vascular; cytology; Myocytes, Smooth Muscle; drug effects; Plant Leaves; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Wistar
- From: China Journal of Chinese Materia Medica 2003;28(8):754-756
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the protecting mechanism of Yixintong for heart ischemia-reperfusion injury at cellular and subcellular levels, by observing the effects of Yixintong on three kinds of calcium channels.
METHODThe effects of Yixintong on Ca2+ influx on leak calcium channel, receptor-operationg calcium channel (ROC) and pulse-dependent calcium channel (PDC) were observed respectively, by using rat aortic smooth muscle cell and radioactive 45Ca technique.
RESULTYixintong has no effects on leak calcium channel, but can inhibit the Ca2+ influx in ROC and PDC significantly.
CONCLUSIONYixintong can inhibit the Ca2+ influx in slow channel in a dose-dependent manner.
