Protective effect of curcumin on experimental liver injury in mice.
- Author:
Yong-gang LIU
1
;
Hou-chang CHEN
;
Yi-ping JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Animals; Aspartate Aminotransferases; blood; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Curcumin; pharmacology; Galactosamine; Lipopolysaccharides; Liver; metabolism; Liver Diseases; blood; metabolism; Male; Malondialdehyde; metabolism; Mice; Nitric Oxide; blood; Protective Agents; pharmacology
- From: China Journal of Chinese Materia Medica 2003;28(8):756-793
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo Study the protective effect of curcumin on three models of experimental liver injury in mice.
METHODThe experimental models of live injury were induced by carbon tetrachloride (CCl4), D-galactosamine (D-Gal N), and Bacillus Calmette-Guerin (BCG) Plus lipolysaccharides (LPS), respectively, in mice. The serum ALT, AST, NO and liver MDA were measured to evaluate the protective effect of curcumin on experimental injury in mice.
RESULTCurcumin (50 mg.kg-1, 100 mg.kg-1, 150 mg.kg-1), like biophenyldicarboxylate, were shown to significantly inhibit the increase of serum ALT, AST, NO and liver molondialdehyde (MDA) content induced by CCl4, D-Gal N, BCG + LPS.
CONCLUSIONCurcumin showed protective effect against liver injury induced by CCl4, D-Gal N, BCG plus LPS.
