The importance and approaches of physicochemical properties analysis of active compounds of traditional Chinese herbs in development of new medicine.
- Author:
Jian FENG
1
;
Ping XIE
Author Information
1. Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan, China. fengjan222@163.net
- Publication Type:Journal Article
- MeSH:
Absorption;
Animals;
Drug Design;
Drug Interactions;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
pharmacokinetics;
Humans;
Medicine, Chinese Traditional;
Plants, Medicinal;
chemistry;
Solubility;
Technology, Pharmaceutical;
methods;
Tissue Distribution
- From:
China Journal of Chinese Materia Medica
2003;28(9):798-890
- CountryChina
- Language:Chinese
-
Abstract:
Biological activity and physicochemical properties are two key factors to screen active compounds of traditional Chinese herbs during early discovery phases. As a great number of the compounds are got in the world, a new strategy is developed to research the physicochemical properties of the compositions of herbs, so that the election of active compounds from the compositions has become more effective and more economical than before. The new strategy and associated technology have emerged and it was used extensively. The physicochemical properties of the compounds of traditional Chinese medicine(TCM) relate to pharmaceutical and ADME (Absorption, distribution, metabolism and elimination), and development, clinical effect and safety are evaluated with the properties. Therefore, the physicochemical properties are important in the development of TCM.
